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What is an MIP[4]SPE?:

Molecularly Imprinted Polymers for Solid Phase Extraction (a.k.a. MIP[4]SPE), are solid phase extraction columns designed for unparalleled selectivity toward a particular target compound, or class of compounds.  MIP[4]SPE combines the selectivity of an antibody with the stability of a polymer.  The benefits provided by MIP[4]SPE compared with conventional silica-based, and mixed-bed SPE columns, include:

  • Cleaner extracts, reduced background interferences

  • Improved sensitivity

  • Consistently high target analyte recovery

  • Reduced sample preparation time

  • Fewer sample clean-up steps

  • Elimination of ion-suppression in LC/MS applications

  • MIPs can also be used for process-scale clean-ups.


In short, MIP delivers better results, greater productivity, and lower costs.

Currently available MIP[4]SPE products:

  • Amphetamines (class specific)

  • beta-Agonist drugs (class specific)

  • beta-Blocker drugs (class specific)

  • beta-Receptor (beta-Agonists + beta-Blockers)

  • Chloramphenicol

  • Clenbuterol

  • Fluoroquinolones (class specific)

  • Nitroimidazoles (class specific)

  • NNAL (carcinogenic tobacco-specific nitrosamine)

  • Non-steroidal anti-inflammatory drugs (NSAIDs)

  • Polycyclic Aromatic Hydrocarbons (PAHs)

  • Riboflavin (Vitamin B2)

  • Tobacco-specific nitrosamines (NNN, NNK, NAB, & NAT)

  • Triazine herbicides (class specific)

  • ExploraSep Method Development Kits

  • others are in development

These standard solid-phase extraction products are available in standard 10 mL column format.  Other formats including 3 mL columns, 96-well plate format, etc., are also available.  MIP sorbents can also be also be formatted to create selective HPLC columns.



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